There are a lot of great places that you can donate your money to help others.  I am going to list five of my favorites.

St Jude Children Hospital
Center for research and treatment of catastrophic diseases in children, primarily pediatric cancers.
Main Web Link-  http://www.stjude.org

Make A Wish

Since 1980, the Make-A-Wish Foundation has enriched the lives of children with life-threatening medical conditions through its wish-granting work. 

Main Web Link- http://www.wish.org

National Center for Missing & Exploited Children

Mission is to help prevent child abduction and sexual exploitation; help find missing children; and assist victims of child abduction and sexual exploitation, their families, and the professionals who serve them.

Main Web Link- http://www.missingkids.com

World Vision

Is a Christian humanitarian organization dedicated to working with children, families and their communities worldwide to reach their full potential by tacking the causes of poverty and injustice.

Main Web Link- http://www.worldvision.org/

Kiva- Loans that change lives